Datasets Discovered: DLBCL Cohort

Sep 15, 2021 11:00:00 AM / by Champions Oncology posted in Lumin Bioinformatics

Importance of the Dataset

Diffuse Large B-Cell Lymphoma (DLBCL) is a cancer of the B cells and is the most common form of non-Hodgkin’s Lymphoma (NHL) among adults. Champions’ DLBCL models encompass various subtypes of the disease, including ABC (Activated B cell), GCB (Germinal Center B cell), and Richter. These models are well-characterized and include patient clinical attributes, disease status, treatment history and in vivo drug responses to a range of therapies, including CHOP or a Rituximab-CHOP (R-CHOP) combination treatment. Champions DLBCL model cohort includes diverse molecular features such as double and triple hit mutations, as well as mutations in several key pathways such as proliferation, oncogenic signaling, and B cell differentiation. This unique dataset includes next generation sequencing (NGS), proteomics and phospho-proteomics from Champions’ DLBCL cohort.

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Lumin Bioinformatics Spotlight: Feature Exploration

Aug 26, 2021 11:00:00 AM / by Champions Oncology posted in Lumin Bioinformatics

Champions Oncology is illuminating the cellular dynamics of cancer by providing a tool to accelerate biomarker discovery for all cancer researchers. Champions proprietary PDX (patient-derived xenograft) models have been shown to recapitulate patient response to clinical treatments1. The Lumin Bioinformatics platform incorporates NGS and proteomic data obtained from Champions unique and highly characterized PDX tumor bank as well as publicly available data sets (i.e. TCGA, CPTAC, GEO).

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What’s behind the mask? Lumin Bioinformatics – using Champions’ powerful data visualization and analytic software to drive target discovery

May 13, 2021 11:00:00 AM / by Champions Oncology posted in Lumin Bioinformatics

Answers provided by Alexis Santana, PhD – Manager, Business Development at Champions Oncology

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